Calorie restriction delays disease onset and mortality in monkeys

New study (Colman et al, 2009) in this week's issue of Science on the effect of calorie restriction over a 20 year period in rhesus macaques. Researchers at the Wisconsin National Primate Research Center examined monkeys under 30% CR and controls matched for baseline intake, age, and weight. According to the abstract:

Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.

Their general findings indicate a clear quantifiable effect of CR in reducing both mortality and age-related morbidities (cancer, cardiovascular disease, metabolic derangements) as well as age-associated loss of gray matter:

Food for thought, though confounding issues such as frequency of eating rather than total amount of caloric intake are not directly addressed.